Tomoyoshi Soga
曽我 朋義 ソガ トモヨシ

環境情報学部教授
政策・メディア研究科委員
生年1959年
学位工学博士
主な兼職理化学研究所植物科学研究センター客員主管研究員、 慶應義塾大学医学部 教授(兼担) 、ヒューマン・メタボローム・テクノロジーズ株式会社 技術顧問
略歴【学歴】
慶應義塾大学工学部応用化学科卒
工学博士 (論博 豊橋技術科学大学)
【主な前職】
横河電機株式会社、横河アナリティカルシステムズ株式会社、
琉球大学客員教授、東京大学分子細胞生物学研究所 非常勤講師
ヒューマン・メタボローム・テクノロジーズ株式会社 取締役
専門分野メタボロミクス、分析化学、がん代謝
所属学会・団体日本分子生物学会、日本分析化学会、日本生化学会、日本質量分析学会、日本癌学会、日本医用マス学会、日本電気泳動分析研究懇談会、日本ヒトプロテオーム学会
主要著作・論文・作品"Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells" Hayashi, Y., Otsuka, K., Ebina, M., Igarashi, K., Takehara, A., Matsumoto, M., Kanai, A., Igarashi, K., Soga, T., Matsui, Y., Proc. Natl. Acad. Sci. USA , 114, 8289-8294, 2017.

"Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes" Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J., Duchen, MR.., Nam, J., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T., Fujita, Y., Nat. Cell Biol. 19, 530-541, 2017.

"The metabolic profile of a rat model of chronic kidney disease" Tanada, Y., Okuda, J., Kato, T., Minamino-Muta, E., Murata, I., Soga, T., Shioi, T., Kimura, T., Peer J. 5, e3352: Doi: 10.7717/peerj.3352., 2017.

“Metabolomics of an in vitro liver model containing primary hepatocytes assembling around an endothelial cell network: comparative study on the metabolic stability and the effect of acetaminophen treatment” Toyoda, Y., Kashikura, K., Soga, T., Tagawa, Y., J. Toxicol. Sci. 42, 445-454, 2017.

"Thymidine Catabolism as a Metabolic Strategy for Cancer Survival" Tabata, S., Yamamoto, M., Goto, H., Hirayama, A., Ohishi, M., Kuramoto, T., Mitsuhashi, A., Ikeda, R., Haraguchi, M., Kawahara, K., Shinsato, Y., Minami, K., Saijo, A., Hanibuchi, M., Nishioka, Y., Sone, S., Esumi, H., Tomita, M., Soga, T., Furukawa, T., Akiyama, S., Cell Reports 19, 1313-1321, 2017.

"Cancer with low cathepsin D levels is susceptible to vacuolar (H+)-ATPase inhibition" Kitazawa, S., Nishizawa, S., Nakagawa, H., Funata, M., Nishimura, K., Soga, T., Hara, T., Cancer Sci108, 1185-1193, 2017.

"Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance" Nijhuis, A., Thompson, H., Adam, J., Paker A., Gammmon, L., Lewis, A., Bundy, J.G., Soga, T., Jalaly, A., Propper, D., Jeffery, R., Suraweera, N., McDonald, S., Thaha, M.A., Feakins, R., Lowe, R., Bishop, C., Silver, A., Hum Mol Genet. 26, 1552-1564, 2017.

"Serum Metabolomic Profiles for Human Pancreatic Cancer Discrimination"*Itoi, T., Sugimoto, M., Umeda, J., Sofuni, A., Tsuchiya, T., Tsuji, S., Tanaka, R., Tonozuka, R., Honjo, M., Moriyasu, F., Kasuya, K., Nagakawa, Y., Abe, Y., Takano, K., Kawachi, S., Shimazu, M., Soga, T., Tomita, M., Sunamura, M., Int. J. Mol. Sci. 18, 767; doi:10.3390/ijms18040767, 2017.

"Modelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs" Yoshitoshi-Uebayashi, E.Y., Toyoda, T., Yasuda, K., Kotaka, M., Nomoto, K., Okita, K., Yasuchika, K., Okamoto, S., Takubo, N., Nishikubo, T., Soga, T., Uemoto, S., Osafune, K., Biochem Biophys Res Commun. 486, 613-619, 2017.

"Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors" Kitazawa, S., Ebara1, S., Ando, A., Baba, Y., Satomi, Y., Soga, T., Hara, T., Oncotarget8, 28922-28938, 2017.

"Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice" Sakata, F., Ito, Y., Mizuno, M., Sawai, A., Suzuki, Y., Tomita, T., Tawada, M., Tanaka, A., Hirayama, A., Sagara, A., Wada, T., Maruyama, S., Soga, T., Matsuo, S., Imai, E., Takei, Y., Lab. Invest. 97, 432-446, 2017.

"Metabolomic profiling as a possible reverse engineering tool for estimating processing conditions of dry-cured hams" Sugimoto, M., Obiya, S., Kaneko, M., Enomoto, A., Honma, M., Wakayama, M., Soga, T., Tomita, M., J. Agric. Food Chem.65, 402-410, 2017.

"A serum metabolomics-based profile in low bone mineral density postmenopausal women" *Miyamoto, T., Hirayama, A., Sato, Y., Koboyashi, T., Katsuyama, E., Kanagawa, H., Miyamoto, H., Mori, T., Yoshida, S., Fujie, A., Morita, M., Watanabe, R., Tando, T., Miyamoto, K., Tsuji, T., Funayama, A., Nakamura, M., Matsumoto, M., Soga, T., Tomita, M., Toyama, Y., Bone 95,1-4, doi:10.1016/j.bone.2016.10.027, 2017.

"Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men" Fukai, K., Harada, S., Iida, M., Kuriara, A., Takeuchi, A., Kuwabara, K., Sugiyama, D., Okamura, T., Akiyama, M., Nishiwaki, Y., Oguma, Y., Suzuki, A., Suzuki, C, Hirayama, A., Sugimoto, M., Soga, T.,c Tomita, M., *Takebayashi, T., PLoS ONE 11, e0164877, 2016.

"Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis" Bardella C, Al-Dalahmah O, Krell D, Brazauskas P, Al-Qahtani K, Tomkova M, Adam J, Serres S, Lockstone H, Freeman-Mills L, Pfeffer I, Sibson N, Goldin R, Schuster-Böeckler B, Pollard, PJ, Soga T, McCullagh JS, Schofield CJ, Mulholland P, Ansorge O, Kriaucionis S, Ratcliffe PJ, *Szele, FG, *Tomlinson I, Cancer Cell 30, 578-594, 2016.

"Stimulating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK" Ogawa, T., Tsubakiyama, R., Kanai, M., Koyama , T., Fujii, T., Iefuji, H., Soga, T., Kume, K., Miyakawa, T., Hirata, D., *Mizunuma, M., Proc. Natl. Acad. Sci. USA 113, 11913-11918, 2016.

"Identification of salivary metabolomic biomarkers for oral cancer screening" Ishikawa, S., *Sugimoto, M., Kitabatake, K., Sugano, A., Nakamura, M., Kaneko, M., Ota, S., Hiwatari, K., Enomoto, A., Soga, T., Tomita, M., Iino, M., Sci. Rep. 6, 31520, 2016.

"Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress" Yamanaka, R., Tabata, S., Shindo, Y., Hotta, K., Suzuki, K., Soga, T., *Oka, K., Sci. Rep. 6, 30027, 2016.

"Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C" *Saito, T., Sugimoto, M., Okumoto, K., Haga, H., Katsumi, T., Mizuno, K., Nishina, T., Sato, S., Igarashi, K., Maki, H., Tomita, M., Ueno, Y., Soga, T., World J. Gastroenterol. 22. 6224-6234, 2016.

"p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming" Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, MS., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., *Yamamoto, M., *Tanaka, K., *Komatsu, M., Nat. Commun. 7, 12030, 2016.

"Effects of fractionated radiation on murine glioma stem cell metabolism" Fujita, S., Osuka, S. Shibao, S., Igarashi, K., Soga, T., *Sampetrean, O., Toho J. Med. 2,45-52, 2016.

"p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling in response to stress" Karigane, D., Kobayashi, H., Morikawa, T., Ootomo, Y., Sakai, M., Nagamatsu, G., Kubota, Y., Goda, N., Matsumoto, M., Nishimura, E. K., Soga, T., Otsu, K., Suematsu, M., Okamoto, S., Suda, T., *Takubo, K., Cell Stem Cell 19, 192-204, 2016.

"Identification of biomarkers for development of end-stage kidney disease in chronic kidney disease by metabolomic profiling" *Kimura, T., Yasuda, K., Yamamoto, R., Soga, T., Rakugi, H., Hayashi, T., Isaka, Y., Sci. Rep. 6, 26138, 2016.

"Smad2/3 are required for immobilization-induced skeletal muscle atrophy" Tando, T., Hirayama, A., Furukawa, M., Sato, Y., Kobayashi, T., Funayama1, A., Kanaji, A., Hao, W., Watanabe, R., Morita, M., Oike, T., Miyamoto, K., Soga, T., Nomura, M., Yoshimura, A., Tomita, M., Matsumoto, M., Nakamura, M., Toyama, Y., *Miyamoto, T. , Biol. Chem. 291, 12184-12194, 2016.

"Profiling of plasma metabolites in postmenopausal women with metabolic syndrome" Iida, M., Harada, S., Kurihara, A., Fukai, K., Kuwabara, K., Sugiyama, D., Takeuchi, A., Okamura, T., Akiyama, M., Nishiwaki, Y., Suzuki, A., Hirayama, A., Sugimoto, M., Soga, T., Tomita, M., Banno, K., Aoki, D., *Takebayashi, T., Menopause 23, 749-758 , 2016.

"Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men" Harada S., Takebayashi T., Kurihara A., Akiyama M., Suzuki A., Hatakeyama Y., Sugiyama D., Kuwabara K., Takeuchi A., Okamura T., Nishiwaki Y., Tanaka T., Hirayama A., Sugimoto M., Soga T., Tomita M., Environ. Health Prev. Med. 21, 18-26, 2016.

"Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK" Nakano, T., Saiki, Y., Kudo, C., Hirayama, A., Mizuguchi, Y., Fujiwara, S., Soga, T., Sunamura, M., Matsumura, N., Motoi, F., Unno, M., Horii, A., Biochem. Biophys. Res. Commun. 464, 1084-1089, 2015.

"Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress" Uetaki, M., Tabata, S., Nakasuka, F., Soga, T., Tomita, M., Sci. Rep. 5, 13896, 2015.

"Alteration of metabolomic profiles by titanium dioxide nanoparticles in human gingivitis model" Garcia-Contreras, R., Sugimoto, M., Umemura, N., Kaneko, M., Hatakeyama, Y., Soga, T., Tomita, M., Scougall-Vilchis, R.J., Contreras-Bulnes, R., Nakajima, H., *Sakagami, H., Biomaterials 57, 33-40, 2015.

"Effects of processing and storage conditions on charged metabolomic profiles in blood" †Hirayama, A., *†Sugimoto, M., Suzuki, A., Hatakeyama, Y., Enomoto, A., Harada, S., Soga, T., Tomita, M., Takebayashi, T., Electrophoresis 36, 2148–2155, 2015. (†These authors contributed equally)

"IDH2 and NPM1 mutations cooperate to activate Hoxa9/Meis1 and hypoxia pathways in acute myeloid leukemia" Ogawara, Y., Katsumoto, T., Aikawa, Y., Shima, Y., Kagiyama, Y., Soga, T., Matsunaga, H., Seki, T., Araki, K., *Kitabayashi, I., Cancer Res. 75, 2005-2016, 2015.

"Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function" Kobayashi, S., Sato, M., Kasakoshi, T., Tsutsui, T., Sugimoto, M., Osaki, M., Okada, F., Igarashi, K., Hiratake, J., Homma, T., Conrad, M., Fujii, J., Soga, T., Bannai, S., *Sato, H., J. Biol. Chem. 290, 8778-8788, 2015.

"Potential Biomarkers of Fatigue Identified by Plasma Metabolome Analysis in Rats" Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., *Kataoka, Y., PLoS ONE 10, e0120106, 2015.

"Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine" Kishikawa, T., *Otsuka, M., Tan, P.S., Ohno, M., Sun, X., Yoshikawa, T., Shibata, C., Takata, A., Kojima, K., Takehana, K., Ohishi, M., Ota, S., Noyama, T., Kondo, Y., Sato, M., Soga, T., Hoshida, Y., Koike, K., Oncotarget 6, 8339-8352, 2015.

"Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD" Mishima, E., Fukuda, S., Shima, H., Hirayama, A., Akiyama, Y., Takeuchi, Y., Fukuda, N. N., Suzuki, T., Suzuki, C., Yuri, A., Kikuchi, K., Tomioka, Y., Ito, S., Soga, T., Abe, T., J. Am. Soc. Nephrol. 26, 1787-1794, 2015.

"Hypoxia Induces a Lipogenic Cancer Cell Phenotype via HIF1α-Dependent and -Independent Pathways" Valli, A., Rodriguez, M., Moutsianas, L., Fischer, R., Fedele, V., Huang, H.L., Van Stiphout, R., Jones, D., Mccarthy, M., Vinaxia, M., Igarashi, K., Sato, M., Soga, T., Buffa, F., Mccullagh, J., Yanes, O., Harris, A., Kessler. B., Oncotarget 6, 1920-1941, 2015.

"Development of quantitative method for determination of γ-glutamyl peptides by capillary electrophoresis tandem mass spectrometry: An efficient approach avoiding matrix effect" Hirayama, A., Igarashi, K., Tomita, M., Soga, T.,J Chromatogr A. 1369, 161-169, 2014.

"Mass spectrometric analysis of L-cysteine metabolism:physiological role and fate of L-cysteine in the enteric protozoan parasite Entamoeba histolytica" Jeelani, G., Sato, D., Soga, T., Watanabe, H., *Nozaki, T., mBio 5, e01995-14, 2014.

"Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse" Xu, F., Sudo, Y., Sanechika, S., Yamashita, J., Shimaguchi, S., Honda, S., Sumi-Ichinose, C., Mori-Kojima, M., Nakata, R., Furuta, T., Sakurai, M., Sugimoto, M., Soga, T., Kondo, K., Ichinose, H., FEBS Lett. 588, 3924-3931, 2014.

"Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage" Mishima, E., Inoue, C., Saigusa, D., Inoue, R., Ito, K., Suzuki, Y., Jinno, D., Tsukui, Y., Akamatsu, Y., Araki, M., Araki, K., Shimizu, R., Shinke, H., Suzuki, T., Takeuchi, Y., Shima, H., Akiyama, Y., Toyohara, T., Suzuki, C., Saiki, Y., Tominaga, T., Miyagi, S., Kawagisihi, Naoki, Soga, T., Ohkubo, T., Yamamura, K., Imai, Y., Masuda, S., Sabbisetti, V., Ichimura, T., Mount, D.B., Bonventre, J.V., Ito, S., Tomioka, Y., Itoh, K., Abe, T., J Am Soc Nephrol. 25, 2316-2326, 2014.

"Thymidine phosphorylase activates NFκB and stimulates the expression of angiogenic and metastatic factors in human cancer cells" Tabata, S., Ikeda, R., Yamamoto, M., Shimaoka, S., Mukaida, N., Takeda, Y., Yamada, K., Soga, T., Furukawa, T., Akiyama, S., Oncotarget 5, 10473-10485, 2014.

"Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism" Yang, M., Su, H., Soga, T., Kranc, K.R., Pollard, P.J. ,Hypoxia 2, 127-142, 2014.

"Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin" Takeuchi, K., Ohishi, M., Endo, K., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., and Soga, T.,Biomark. Insights.. 9, 61-66, 2014.

"Fetal Growth Retardation and Lack of Hypotaurine in Ezrin Knockout Mice" Nishimura, T., Higuchi1, K., Sai, Y., Sugita, Y., Yoshida, Y., Tomi, M., Wada, M., Wakayama, T., Tamura, A., Tsukita, S., Soga, T., and Nakashima, E., PLoS ONE 9, e105423, 2014.

"Reconstruction of insulin signal flow from phosphoproteome and metabolome data" Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K.I., Kashikura, K., Endo, K., Ikeda, K., Soga, T., Kuroda, S., Cell Rep. 8, 1171-1183, 2014.

"Metabolome analysis based on capillary electrophoresis-mass spectrometry" Hirayama, A., Wakayama, M., Soga, T. , Trends Anal. Chem. 61, 215-222, 2014.

"Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol" Cheng, K., Lee, B., Masuda, T., Ito, T., Ikeda, K., Hirayama, A., Deng, L., Dong, J., Shimizu, K., Soga, T., Tomita, M., Palsson, B. O. & Robert, M., Nat. Commun. 5, 3233, 2014.

"Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis" Obata, F., Kuranaga, E., Tomioka, K., Ming M., Takeishi, A., Chen, C., Soga, T., Miura, M., Cell Rep. 7, 821-833, 2014.

"Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation" Ohka, F., Ito, M., Ranjit, M., Senga, T., Motomura, A., Motomura, K., Saito, K., Kato, K., Kato, Y., Wakabayashi, T., Soga, T., Natsume, A., Tumor Biol., 35, 5911-5920, 2014.

"Metabolomic Analysis of the Effects of Omeprazole and Famotidine on Aspirin-induced Gastric Injury" Takeuchi, K., Ohishi, M., Endo, K., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., Soga, T., Metabolomics, Metabolomics, 10, 995-1004, 2014.

"Comparative metabolite profiling of foxglove aphids (Aulacorthum solani Kaltenbach) on leaves from resistant and susceptible soybean strains" Sato, D., Sugimoto, M., Akashi, H., Tomita, M., Soga, T., Mol. BioSyst.10, 909-915, 2014.

"Rare insights into cancer biology" Adam, J., Yang, M., Soga, T., and Pollard, P.J., Oncogene 33, 2547-2556, 2014.

"Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women" Yamatani, H., Takahashi, K., Yoshida, T., Soga, T., Kurachi, H., Menopause 21, 170-176, 2014.

"Metabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line" Sakagami, H., Sugimoto, M., Tanaka, S., Onuma, H., Ota, S., Kaneko, M., Soga, T., Tomita, M., Metabolomics10, 270-279, 2014.
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"Cancer metabolism: key players in metabolic reprogramming" Soga, T., Cancer Sci.104, 275-81, 2013.

"A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia", Adam, J., Yang, M., Bauerschmidt, C., Kitagawa, M., O’Flaherty, L., Maheswaran, P., O¨ zkan, G., Sahgal, N., Baban, D., Kato, K., Saito, K., Iino, K., Igarashi, K., Stratford, M., Pugh, C., Tenant, D., Ludwig, C., Davies, B., Ratcliffe, P. J., El-Bahrawy, M., Ashrafian, H., Soga, T., and Pollard, P. J. , Cell Rep. 3, 1440-1448, 2013.

"Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency" Ternette N., Yang M., Laroyia M., Kitagawa M., O'Flaherty L., Wolhulter K., Igarashi K., Saito K., Kato K., Fischer R., Berquand A., Kessler B.M., Lappin T., Frizzell N., Soga T., Adam J, Pollard P.J., Cell Rep. 3, 689-700. 2013.

"Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells" Takubo, K., Nagamatsu, G., Kobayashi, C. I, Nakamura-Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Johnson, R. S, Rahimi, Y., Soga, T., Hirao, A., Suematsu, M., Suda, T., Cell Stem Cell. 12, 49-61, 2013.

"The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns" Noguchi, R., Kubota, H., Yugi, K., Toyoshima, Y., Komori, Y., Soga, T., Kuroda, S., Mol Syst Biol. 9:664, doi:10.1038/msb.2013.19, 2013.

"Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors" Uema, N., Ooshio, T., Harada, K., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Ohta, K., Ali, M.A., Katano, M., Soga, T., Nakanuma, Y., Okuda, A., Hirao, A.,Am. J. Pathol. 183, 592-603, 2013.

"Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress" Kimura, T., Takahashi, A., Takabatake, Y., Namba, T, Yamamoto, T., Kaimori, J.Y., Matsui, I., Kitamura, H., Niimura, F., Matsusaka T., Soga, T., Rakugi, H., Isaka, Y. Autophagy 9, 1876-86, 2013.

"Metabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis" Karasawa, T., Saito, T., Ueno, Y., Sugimoto, M., Soga, T., Int J Med Sci. 10, 1575-1577, 2013.

"Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: A metabolomics analysis" Saito, T., Sugimoto, M., Igarashi, K., Saito, K., Shao, L., Katsumi, T., Tomita, K., Sato, C., Ishii, R., Okumoto, K., Nishise, Y., Watanabe, H., Tomita, M., Ueno, Y., Soga, T.,Metabolism, 62, 1577-1586, 2013.

"Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice", Okuda, J., Niizuma, S., Shioi, T., Kato, T., Inuzuka, Y., Kawashima, T., Tamaki, Y., Kawamoto, A., Tanada, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Adachi, S., Soga, T., Takemura, G., Kondoh, H., Kita, T., Kimura, T., PLoS ONE 8, e72173, 2013.

"Oncometabolites: Linking Altered Metabolism with Cancer" Yang, M., Soga, T., and Pollard, P. J., J. Clin. Invest., 123, 3652-3658, 2013.

"Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart" Shimura, D., Nakai, G., Jiao, Q., Osanai, K., Kashikura, K., Endo, K., Soga, T., Goda, N., Minamisawa, S., Am J Physiol Heart Circ Physiol. 305, H494-505,2013.

"Dynamic simulation and metabolome analysis of long-term erythrocyte storage in adenine-guanosine solution" Nishino, T., Yachie-Kinoshita1, A., Hirayama, A., Soga, T., Suematsu, M., Tomita, M., PLoS ONE 8, e71060, 2013.

"Time-resolved metabolomics of a novel trebouxiophycean alga using 13CO2 feeding" Ito, T., Sugimoto, M., Toya, Y., Ano, Y., Kurano, N., Soga, T., Tomita, M., J Biosci Bioeng. 116, 408-415, 2013.

"Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients" Tsuruoka, M., Hara, J., Hirayama, A., Sugimoto, M., Soga, T., Shankle, W.R., Tomita , M., Electrophoresis 34, 2865-2872, 2013.

"Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy" Maekawa, K.#, Hirayama, A.#, Iwata Y.#, Tajima Y., Nishimaki-Mogami T., Sugawara S., Ueno, N., Abe, H., Ishikawa M., Murayama M., Matsuzawa Y., Nakanishi H., Ikeda K., Arita M., Taguchi, R., Minamino N., Wakabayashi, S., Soga T., Saito, Y., J. Mol. Cell. Cardiol59, 76-85, 2013. (#Contributed equally to this work)

"Metabolic Profiling to Identify Potential Serum Biomarkers for gastric ulceration induced by non-steroid anti-inflammatory drugs" Takeuchi, K., Ohishi, M., Ota, S., Suzumura, K., Naraoka, H., Ohata,T., Seki, J., Miyamae, Y., Honma, M., Soga, T., J. Proteome Res.12, 1399-1407, 2013.

"Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact" Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H., Am J Pathol. 182, 1800-1810, 2013.

"Metabolome profiling of floral scent production in Petunia axillaris" Oyama-Okubo, N., Sakai , T., Ando, T., Nakayama, M., Soga, T., Phytochemistry 90, 37-42, 2013.

"Metabolomic study of Chilean biomining bacteria Acidithiobacillus ferrooxidans strain Wenelen and Acidithiobacillus thiooxidans strain Licanantay" Marti´nez, P., Ga´lvez, S., Ohtsuka, N., Budinich, M., Corte´s, M.P., Serpell, C., Nakahigashi, K., Hirayama, A., Tomita, M., Soga, T., Marti´nez, S., Maass, A., Parada, P., Metabolomics 9, 247-257, 2013.

"Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles" Sugimoto, M., Saruta, J., Matsuki, C., To, M., Onuma, H., Kaneko, M., Soga, T., Tomita, M., and Tsukinoki, K., Metabolomics 9, 454-463, 2013.

"Metabolic and morphological changes of an oil accumulating trebouxiophycean alga in nitrogen-deficient conditions" Ito, T., Tanaka, M., Shinkawa, H., Nakada, T., Ano, Y., Kurano N., Soga T., Tomita, M., Metabolomics 9, Supplement, 178-187, 2013.

"Metabolomic Profiling of Lung and Prostate Tumor Tissues by Capillary Electrophoresis Time-of-flight Mass Spectrometry" , Kami, K., Fujimori, T., Yamamoto, H., Ohashi, Y., Sugiyama, N., Ishihama, Y., Tomita, M., Soga, T., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., and Esumi, H. , Metabolomics 9, 444-453, 2013.

"Acetaminophen-induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling Around an Endothelial Cell Network" Toyoda, Y., Tamai, M., Kashikura, K., Kobayashi, S., Fujiyama, Y., Soga, T., Tawaga, Y., Drug Metab. Dispos. 40, 169-177, 2012.

"A medium-chain fatty acid as an alternative energy source in mouse preimplantation development" Yamada, M., Takanashi, K., *Hamatani, T., Hirayama, A., Akutsu, H., Fukunaga, T. Ogawa, S., Sugawara, K., Shinoda, K., Soga, T., Umezawa, A., Kuji, N., Yoshimura ,Y. and Tomita, M.,Sci. Rep.2, 930., 2012.

"Pilot Study of Changes in Salivary Metabolic Profiles Induced by Template Therapy" Tanaka, S., Taga, H., Maehara, K., *Kaneshima, A., Machino, M., Onuma, H., Kaneko, M., Sakagami, H., Sugimoto, M., Soga, T. and Tomita, M., In Vivo 26, 1015-1020,2012.

"mTORC1 is Essential for Leukemia propagation but Not Stem Cell Self- renewl" Hoshi, T., Tadokoro, Y., Naka, K., Ooshio, T., Muraguchi, T., Sugiyama, N., Soga, T., Araki, K., Yamamura, K., Hirao, A., J. Clin. Invest. 122, 2114-2129. 2012.

"Human blood metabolite timetable indicates internal body time" Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K., Mishima, K., Soga, T., Ueda, H.R., Proc. Natl. Acad. Sci. USA 109, 15036-15041, 2012.

"Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue" Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., ,Sato, S., Takanashi, M., Funayama, M., Hirayama, A., Soga, T., Hishiki, T., Suematsu, M., Yagi, T., Ito, D., Kosakai, A., Hayashi, K., Shouji, M., Nakanishi, A., Suzuki, N., Mizuno, Y., Mizushima, N., Amagai, M., Uchiyama, Y., Mochizuki, H., Hattori, N., Okano H., Mol Brain. 5:35, 2012.

"Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis" Hirata, Y., Ikeda, K., Sudoh, M., Tokunaga, Y., Suzuki, A., Weng, L., Ohta, M., Tobita, Y., Okano, K., Ozeki, K., Kawasaki, K., Tsukuda, T., Katsume, A., Aoki, Y., Umehara, T., Sekiguchi, S., Toyoda, T., Shimotohno, K., Soga, T., Nishijima, M., Taguchi, R., Kohara, M.,PLoS Pathog. 8, e1002860.

"Dramatic Increase in Glycerol Biosynthesis upon Oxidative Stress in the Anaerobic Protozoan Parasite Entamoeba histolytica" Husain, A., Sato, D., Jeelani, G., Soga, T., Nozaki, T., PLoS Negl Trop Dis 6(9): e1831, 2012.

"Sheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis" Hirayama, A., Tomita, M., and *Soga, T., Analyst 137, 5026-5033, 2012.

"Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy" Hirayama, A., Nakashima, E., Sugimoto, M., Akiyama, S., Sato, W., Maruayama, S., Matsuo, S., Tomita, M., Yuzawa, Y., Soga, T., Anal Bioanal Chem.404, 3101-3109, 2012.

"Metabolomic Profiling Rationalized Pyruvate Efficacy in Cybrid Cells Harboring MELAS Mitochondrial DNA Mutations" Kami, K., Fujita, Y., Igarashi, S., Koike, S., Sugawara, S., Ikeda, S., Sato, N., Ito, M., Tanaka, M., Tomita, M., Soga, T. , Mitochondrion 12, 644-53, 2012.

"In vivo role of aldehyde reductase" Takahashi, M., Miyata, S., Fujii, J., Inai, Y., Ueyama, S., Araki, M., Soga, T., Fujinawa, R., Nishitani C., Ariki S., Shimizu T., Abe T., Ihara Y., Nishikimi, M., Kozutsumi Y., Taniguchi N., and Kuroki, Y., Biochim. biophys. Acta 1820, 1787–1796, 2012.

"A Metabolomic approach for clarifying the effect of AST-120 in 5/6 nephrectomized rats by CE-MS" Akiyama, Y., Takeuchi, Y., Kikuchi, K., Mishima, E., Yamamoto, Y., Suzuki, C., Toyohara, T., Suzuki, T., Ito, S., Soga, T., Abe, T., Toxins 4, 1309-1322,2012.

"The emerging role of fumarate as an oncometabolite" Yang, M., Soga, T., Pollard, P.J., Adam, J., Front. Oncol. Front. Oncol. 2, 85, doi: 10.3389/fonc.2012.00085, 2012.

"L-Carnitine Prevents the Development of Ventricular Fibrosis and Heart Failure with Preserved Ejection Fraction in Hypertensive Heart Disease" Omori, Y., Ohtani, T., Sakata, Y., Mano, T., Takeda, Y., Tamaki, S., Tsukamoto. Y., Kamimura, D., Aizawa, Y., Miwa, T., Komuro, I., Soga, T., Yamamoto, K., J. Hypertens. 30, 1834-44. 2012.

"Clarification as to Why Alcoholic Beverages Have the Ability to Induce Superconductivity in Fe1+dTe1-xSx" Deguchi, K., Sato, D., Sugimoto, M., Hara, H., Kawasaki, Y., Demura, S., Watanabe, T., Denholme, S. J., Okazaki, H., Ozaki, T., Yamaguchi, T., Takeya, H., Soga, T., Tomita, M., Takano, Y., Supercond. Sci. Technol. 25(8), 084025, 2012.

"Bioinfomatics Tools for Mass Spectroscopy -Based Metabolomic Data Processing and Analysis" Sugimoto, M., Kawakami, M., Robert, M., Soga, T., Tomita, M. Curr. Bioinf., 7, 96-108, 2012.

"Changes in the Charged Metabolite and Sugar Profiles of Pasteurized and Unpasteurized Japanese Sake with Storage" Sugimoto, M., Kaneko, M., Onuma, H., Sakaguchi, Y., Mori, M., Abe, S., Soga, T., Tomita, M., J. Agric. Food Chem. 60, 2586-2593, 2012.

"Profiling of the Charged Metabolites of Traditional Herbal Medicines Using Capillary Electrophoresis time-of-flight Mass Spectrometry" Iino, K., Sugimoto, M., Soga, T., Tomita, M., Metabolomics 8, 99-108, 2012.

"Antihypertensive Effects of Unripe Persimmon (Diospyros kaki L.cv. Hiratanenashi) Fruit and Its Component in Spontaneously Hypertensive Rats" Liu, C., Kurakane, S., Takita, J., Itano R., Soga, T., Oikawa A., and Igarashi, K., Food Sci. Technol. Res. 18, 391-398, 2012.

"MMMDB: Mouse Multiple Tissue Metabolome Database" Sugimoto, M., Ikeda, S., Niigata, K., Tomita, M., Sato, H., Soga, T. Nucl. Acids Res. 40 (D1): D809-D814. 2012.

"Analysis of Liver Metabolism in a Rat Model of Heart Failure" Kato, T., Niizuma, S., Inuzuka, Y., Kawashima, T., Okuda, J., Kawamoto A., Tamai, Y., Iwanaga, Y., Soga, T., Kita, T., Kimura, T., Shioi, T., Int. J. Cardiol. 161, 130-136, 2012.

"Non-targeted metabolite profiling in activated macrophage secretion" Sugimoto, M., Sakagami, H., Yokote, Y., Onuma, H., Kaneko, M., Mori, M., Sakaguchi, Y., Soga, T., Tomita, M., Metabolomics Metabolomics 8, 624-633, 2012.

"Serum Metabolomics Reveals γ-glutamyl Dipeptides as Biomarkers for discrimination among Different Forms of Liver Disease" Soga, T., Sugimoto, M., Honma, M., Mori, M., Igarashi, K., Kashikura, K., Ikeda, S., Hirayama, A., Yamamoto, T., Yoshida, H., Otsuka, M., Tsuji, S., Yatomi, Y., Sakuragawa, T., Watanabe, H., Nihei, K., Saito, T., Kawata, S., Suzuki, H., Tomita, M., Suematsu, M.,J. Hepatol. 55, 896-905, 2011.

"Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling" Adam, J., Hatipoglu, E., O’Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban D., Nye, E., Stamp, G.W., Wolhuter, K., Stevens, M., Fischer, R., Carmeliet, P., Maxwell, P.H., Pugh, C.W., Frizzell, N., Soga, T., Kessler, B.M., El-Bahrawy, M., Ratcliffe, P.J., Pollard, P.J. Cancer Cell 20, 524-537, 2011.

"Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway" Deng, L., Shoji, I., Ogawa, W., Kaneda, S., Soga, T., Jiang, D., Ide, Y., Hotta, H., J. Virol. 85, 8556-8568, 2011.

"Use of Serum and Urine Metabolome Analysis for the Detection of Metabolic Changes in Patients with Stage 1-2 Chronic Kidney Disease" Hayashi, K., Sasamura, H., Hishiki, T., Suematsu, M., Ikeda, S., Soga, T., Itoh, H., Nephro-Urol. Mon. 3, 164-171, 2011.

"A Novel Mechanism Regulates H2S and SO2 production in Saccharomyces cerevisiae" Yoshida, S., Imoto, J., Minato, T., Oouchi, R., Kamada, Y., Tomita, M., Soga, T., Yoshimoto, H.,Yeast 28, 109-121, 2011.

"Disruption of HIF-1α in Hepatocytes Impairs Glucose Metabolism in Diet-induced Obesity Mice" Ochiai, D., Goda, N., Hishiki, T., Kanai, M., Senoo-Matsuda, N., Soga, T., Johnson, R.S., Yoshimura, Y., Suematsu, M., Biochem. Biophys. Res. Commun 415, 445-449, 2011.

"GTP-dependent RNA 3'-terminal Phosphate Cyclase from the Hyperthermophilic Archaeon Pyrococcus furiosus" Sato, A., Soga, T., Igarashi, K., Takesue, K., Tomita, M., Kanai, A., Genes Cells 16, 1190-1199, 2011.

"Transcriptional Regulation of Organic Anion Transporting Polypeptide SLCO4C1 as a New Therapeutic Modality to Prevent Chronic Kidney Disease" Suzuki, T., Toyohara, T., Akiyama, Y., Takeuchi, Y., Mishima, E., Suzuki, C., Ito, S., Soga, T., Abe, T., J. Pharm. Sci. 100, 3696-3707, 2011.

"Sex-dependent Hepatic Transcripts and Metabolites in the Development of Glucose Intolerance and Insulin Resistance in Zucker Diabetic Fatty Rats" Gustavsson, C., Soga, T., Wahlström, E, Vesterlund, M, Azimi, A., Norstedt, G., Tollet-Egnell, P., J. Mol. Endcrinol. 47, 129-143, 2011.

"Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury" Kimura, T., Takabatake, Y., Takahashi, A., Kaimori, J., Matsui, I., Namba, T., Kitamura, H., Niimura, F., Matsusaka, T., Soga, T., Rakugi, H., Isaka, Y., J. Am. Soc. Nephrol. 22, 902-913, 2011.

"Metabolomic Anatomy of an Animal Model Revealing Homeostatic Imbalances in Dyslipidaemia" Ooga, T., Sato, H., Nagashima, A., Sasaki, K., Tomita, M., Soga, T., Ohashi, Y., Mol. Biosyst. 7, 1217-23, 2011.

"Positive Autoregulation Delays the Expression Phase of Mammalian Clock Gene Per2" Ogawa, Y., Koike, N., Kurisawa. G., Soga, T., Tomita, M., Tei, H., PLoS ONE 6(4), e18663, 2011.

"Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver" Sugiura, T., Kato, S., Shimizu, T., Wakayama, T., Nakamichi, N., Kubo, Y., Iwata, D., Suzuki, K., Soga, T., Asano, M., Iseki, S., Tamai, I., Tsuji, A. and Kato, Y., Drug Metab Dispos 38, 1665-1672, 2010.

"A Systematic Survey of in vivo Obligate Shaperonin-dependent Substrates" Fujiwara, K., Ishihama, Y., Nakahigashi, K., Soga, T., *Taguchi, H., EMBO J. 29, 1552-1564, 2010.

"Metabolomic Identification of the Target of the Filopodia Protrusion Inhibitor Glucopiericidin A" Kitagawa, M., Ikeda, S., Tashiro, E., Soga, T., *Imoto, M., Chem. Biol. 17, 989-998, 2010.

"Metabolome Analysis Revealed Increase in S-methylcysteine and Phosphatidylisopropanolamine Synthesis upon L-cysteine Deprivation in The Anaerobic Protozoan Parasite Entamoeba Histolytica" Husain, A., Sato, D., Jeelani, G., Suematsu, M., Soga, T., Nozaki, T.,J. Biol. Chem. 285, 39160-39170, 2010.

"Two Atypical-cysteine-regulated NADPH-dependent Oxidoreductases Involved in Redox Maintenance, L-cystine and Iron Reduction, and Metronidazole Activation in the Enteric Protozoon Entamoeba Histolytica" Jeelani, G., Husain, A., Sato, D., Ali, V., Suematsu, M., Soga, T., Nozaki, T., J. Biol. Chem. 285, 26889-26899, 2010.

"Unveiling Cellular Bbiochemical Reactions via Metabolomics-driven Approaches" *Saito, N., Ohashi, Y., Soga, T., Tomita, M., Curr. Opi. Microbiol. 13, 358-362, 2010.

"Prediction of metabolite identity from accurate mass, migration time prediction and isotopic pattern information in CE-TOFMS data" Sugimoto, M., Hirayama, A., Robert, M., Abe, S., Soga, T., Tomita, M., Electrophoresis 31, 1-8, 2010.

"13C-Metabolic Flux Analysis for Batch Culture of Escherrichia coli and Its pyk and pgi Gene Knockout Mutants Based on Mass Isotopomer Distribution of Intracellular Metabolites" Toya, Y., Ishii, N., Nakahigashi, K., Hirasawa, T., Soga, T., Tomita, M., Shimizu, K., Biotechnol. Prog. 26, 975-992, 2010.

"Differential Metabolomics Software for Capillary Electrophoresis-Mass Spectrometry Data Analysis" *Sugimoto, M., Hirayama, A., Ihiskawa, T., Baran, R., Robert, M., Uehara, K., Soga, T., Tomita, M., Metabolomics 6, 27-41, 2010.

"Capillary Electrophoresis Mass Spectrometry-based Saliva Metabolomics Identifies Oral, Breast and Pancreatic Cancer-Specific Profiles" *Sugimoto, M., Wong, D., Hirayama, A., Soga, T., Tomita, M., Metabolomics 6, 78-95, 2010.

"Metabolomic Profiles and Sensory Attributes of Edamame under Various Storage Duration and Temperature Conditions" Sugimoto, M., Goto, H., Ito, M., Onuma, H., Suzuki, A., Abe, S., Tomita, M., Soga, T., J. Agric. Food Chem. 58, 8418-8425, 2010.

"Metabolomic profiling of uremic solutes in CKD patients" Toyohara, T., Akiyama, Y., Suzuki, T., Takeuchi, Y., Mishima, E., Tanemoto, M., Momose, A., Toki, N., Sato, H., Nakayama, M., Hozawa, A., Tsuji, I., Ito, S., Soga, T. and Abe. T., Hypertens. Res. 33, 944-952, 2010.

"MassBank: A Public Repository for Sharing Mass Spectral Data for Life Sciences" Horai, H., Arita, M., Kanaya, S., Nihei, Y., Ikeda, T., Suwa, K., Ojima, Y., Tanaka, K., Tanaka, S., Aoshima, K., Oda, Y., Kakazu, Y., Kusano, M., Tohge, T., Matsuda, F., Sawada, Y., Horai, Y. M., Nakanishi, H., Ikeda, K., Akimoto, N., Maoka, T., Takahashi, H., Ara, T., Sakurai, N., Suzuki, H., Shibata, D., Neumann, S., Iida, T., Tanaka, K., Funatsu, K., Matsuura, F., Soga, T., Taguchi, R., Saito, K., Nishioka, T., J. Mass Spectro. 45, 703-714, 2010.

"Cytotoxic Effect of Amide Derivatives of Trifluoromethionine against The Enteric Protozoan Parasite Entamoeba histolytica" Sato, D., Kobayashi, S., Yasui, H., Shibata, N., Toru, T., Yamamoto, M., Tokoro, G., Ali, V., Soga, T., Takeuchi, T., Suematsu, M., Nozaki, T., Int. J. Antimicrob. Agents. 35, 56-61, 2010.

"Correlation between Sensory Evaluation Scores of Japanese Sake and their Metabolome Profiles" *Sugimoto, M., Koseki, T., Hirayama, A., Abe, S., Sano, T., Tomita, M., Soga, T., J. Agric. Food Chem. 58, 374-383, 2010.

"Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure" Kato, T., Niizuma, S., Inuzuka, Y., Kawashima, T., Okuda, J., Yamaki, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Soga, T., Kita, T., Kimura, T., Shioi, T., Circ. Heart Fail., 3, 420-430, 2010.

"Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1" Kato, Y., Kubo, Y., Iwata, D., Kato, S., Sudo, T., Sugiura, T., Kagaya, T., Wakayama, T., Hirayama, A., Sugimoto, M., Sugihara, K., Kaneko, S., Soga, T., Asano, M., Tomita, M., Matsui, T., Wada, M., Tsuji, A., Pharm. Res., 27, 832-840, 2010.

"Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of rat liver" Sakuragawa, T., Hishiki, T., Ueno, Y., Ikeda, S., Soga, T., Yachie-Kinoshita, A., Kajimura, M., Suematsu, M., J. Clin. Biochem. Nutr., 46, 126-134, 2010.

"Phylogenetic position of a rare loricated green alga, Cephalomonas granulata N. L. Higinb (Volvocales, Chlorophyceae)" Nakada, T., Soga, T., Tomita, M., Phycol. Res. 58, 62-68, 2010.

"Chlorogonium complexum sp. nov. (Volvocales, Chlorophyceae), and morphological evolution of Chlorogonium" Nakada, T., Soga, T., Tomita, M., Nozaki, H., Eur. J. Phycol. 45, 97-106, 2010.

"Measurement of Internal Body Time by Blood Metabolomics" Minami, Y., Kasukawa, T., Kakazu, Y., Iigo, M., Sugimoto, M., Ikeda, S., Yasui, A., van der Horst, G., Soga, T.,* Ueda, H., Proc. Natl. Acad. Sci. USA 106, 9890-9895, 2009.

"Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-flight Mass Spectrometry" Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., Tomita, M., Esumi, H., Soga, T.,* Cancer Res. 69, 4918-4925, 2009.

"Metabolomic Profiling of Anionic Metabolites by Capillary Electrophoresis Mass Spectrometry" Soga, T.,* Igarashi, K., Itoh, C., Mizobuchi, K., Zimmermann, H., Tomita, M., Anal. Chem. 81, 6165-6174, 2009.

"Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism" Nakahigashi, K., Toya, Y., Ishii, N., Soga, T., Hasegawa, M., Watanabe, H., Takai, Y., Honma, M., Mori, H., Tomita, M., Mol. Syst. Biol., 5, 306, doi:10.1038/msb.2009.65

"Degradation of ppGpp by Nudix Pyrophosphatase Modulates the Transition of Growth Phase in the Bacterium Thermus thermophilus" Ooga, T., Ohashi, Y.,* Kuramitsu, S., Koyama, Y., Tomita, M., J. Biol. Chem. 284, 15549-15556, 2009.

"Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli" Saito, N., Robert, M., Kochi, H., Matsuo, G., Kakazu, Y., Soga, T., Tomita, M., J. Biol. Chem. 109, 16442-16451, 2009.

"SLCO4C1 transporter eliminates uremic toxins preventing hypertension and renal inflammation" Toyohara, T., Suzuki, T., Morimoto, R., Akiyama, Y., Souma, T., Shiwaku, H.O., Takeuchi, Y., Mishima, E., Abe, M., Tanemoto, M., Masuda, S., Kawano, H., Maemura, K., Nakayama, M., Sato, H., Mikkaichi, T., Yamaguchi, H., Fukui, S., Fukumoto, Y., Shimokawa, H., Inui, K., Tetasaki, T., Goto, J., Ito, S., Hishinuma, T., Rubera, I., Tauc, M., Fujii-Kuriyama, Y., Yabuuchi, H., Moriyama, Y., Soga, T., Abe, T., J J. Am. Soc. Nephrol. 20(12), 2546-2555, 2009.

"Rescue of anemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes" Iuchi, Y., Okada, F., Takamiya, R., Kibe, N., Tsunoda, S., Nakajima, O., Toyoda, K., Nagae, R., Suematsu, M., Soga, T., Uchida, K., Fujii, J. Biochem. J. 422, 313-320, 2009.

"HIF-1α; is necessary to support gluconeogenesis during liver regeneration" Tajima, T., Goda, N., Fujiki, N., Hishiki, T., Nishiyama, Y., Senoo-Matsuda, N., Shimazu, M., Soga, T., Yoshimura, Y., Johnson, R.S., Suematsu, M., Biochem. Bioph. Res. Co. 387, 789-794, 2009.

"In Silico Modeling and Metabolome Analysis of Long-stored Erythrocytes to Improve Blood Storage Methods" Nishino, T., Yachie-Kinoshita, A., Hirayama, A., Soga, T., J. Biotechnol. J. Biotechnol. 144, 212-223, 2009.

"Mono-(2-ethylhexyl) phthalate Targets Glycogen Debranching Enzyme and Affects Glycogen Metabolism in Rat Testis" Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M., Handa, H., Toxicol. Sci. 109, 143-151, 2009.

"Chlorogonium complexum sp. nov. (Volvocales, Chlorophyceae), and Morphological Evolution of Chlorogonium" Nakada, T., Soga, T., Tomita, M., Nozaki, H., Eur. J. Phycol. 45, 97-107, 2010.

"Cystathionine β-synthase as a Carbon Monoxide-sensitive Regulator of Bile Excretion" Shintani, T., Iwabuchi, T., Soga, T., Kato,Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakurakawa, T., Ishikawa, K., Goda, N., Yitagawa, Y., Kajiyama, M., Matsumoto, K., *Suematsu, M., Hepatology 49, 141-150, 2009.

“Development Bottom-fermenting Saccharomyces Strains That Produce High SO2 Levels, Using Integrated Metabolome and Transcriptome Analysis”, Yoshida, S., Imoto, J., Minato, T., Oouchi, R., Sugihara, M., Imai, T., Ishiguro, T., Mizutani, S., Tomita, M., Soga, T. Appl. Environ. Microbiol. 74, 2787-2796, 2008.

“Time-resolved Metabolomics Reveals Metabolic Modulation in Rice Foliage”, Sato, S., Arita, M., Soga, T., Nishioka, T., Tomita, M.,BMC Systems Biology doi:10.1186/1752-0509-2-51, 2, 51, 2008.

“Depiction of Metabolome Changes in Histidine-starved Escherichia coli by CE-TOFMS”, Ohashi, Y., Hirayama, A., Ishikawa, T., Nakamura, S., Shimizu, K., Ueno, Y., Tomita, M., *Soga, T., Mol. BioSyst. 4, 135-147, 2008.

“Multiple Highthroughput Analyses Monitor The Response of E. coli to Perturbations”, Ishii, N., Nakahigashi, K., Baba, T., Robert, M., Soga, T., Kanai, A., Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P.Y., Kakazu, Y., Sugawara, K., Igarashi, S.,Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., *Tomita, M.,Science 316, 593-597, 2007. (equally contribution).

“Roles of Hemoglobin Allostery in Hypoxia-induced Metabolic Alterations in Erythrocytes: Simulation and Its Verification by Metabolome Analysis”, Kinoshita, A., Tsukada, K., Soga, T., Hishiki, T., Ueno, Y., Nakayama, Y., Tomita, M., *Suematsu, M., J. Biol. Chem. 282, 10731-10741, 2007.

“Analysis of Nucleotides by Pressure-Assisted Capillary Electrophoresis Mass Spectrometry Using Silanol Mask Technique”, *Soga, T., Ishikawa, T., Igarashi, S., Sugawara, K., Kakazu Y., Tomita, M., J. Chromatogr. A 1159, 125-133, 2007.

“Polymer Entrapment in Polymerized Silicate for Preparing Highly Stable Capillary Coatings in CE and CE-MS”, Monton, R. M. N., Tomita, M., *Soga, T., *Ishihama, Y., Anal. Chem. 79, 7838-7844, 2007.

“Microelectrospray Interface with Coaxial Sheath Flow for High Resolution CE-MS Separation”, Hashimoto, M., *Ishihama, Y., Tomita, M., Soga, T., Rapid Commun. Mass Spectrom. 21, 3579-3584, 2007.

“Metabolome Analysis by Capillary Electrophoresis - Mass Spectrometry”, Monton, M. R. N., *Soga, T., J. Chromatogr. A 1168, 237-246, 2007.

“Visualization of Three-way Comparisons of Omics Data” Baran, R., *Robert, M., Suematsu, M., Soga, T., Tomita, M., BMC Bioinformatics doi:10.1186/1471-2105-8-72, 8, 72, 2007.

“Direct measurement of isotopomer of intracellular metabolites using capillary electrophoresis time-of-flight mass spectrometry for efficient metabolic flux analysis”, Toya, Y., Ishii, N., Hirasawa, T., Naba, M., Hirai, K., Sugawara, K., Igarashi, S., Shimizu, K., Tomita, M., *Soga, T., J. Chromatogr. A 1159, 134-141, 2007.

“P-BOSS: A New Filtering Method for Treasure Hunting in Metabolomics”, Morohashi, M., Shimizu, K., Ohashi, Y., Abe, J., Mori, H., Tomita, M., *Soga, T., J. Chromatogr. A 1159, 142-148, 2007.

“Model based definition of population heterogeneity and its effects on metabolism in sporulating Bacillus subtilis”, Morohashi, M., *Ohashi, Y., Tani S., Ishii, K., Itaya, M., Nanamiya, H., Kawamura, F., Tomita, M., Soga, T., J. Biochem. 142, 183-191, 2007.

“Differential Metabolomics Reveals Ophthalmic Acid As An Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption”,Soga, T., Baran, R., Suematsu M., Ueno, Y., Ikeda, S., Sakurakawa T., Kakazu, Y., Ishikawa, T., Robert, M., Nishioka, T., Tomita, M., J. Biol. Chem. 281, 16768-16776, 2006.

“A metabolomics approach for enzyme discovery ”, Saito, N., Robert, M., Kitamura, S., Baran, R., Soga, T., Mori, H., Nishioka, T., Tomita, M., J. Proteome Res. 5, 1979-1987, 2006.

“MathDAMP: a package for differential analysis of metabolite profiles”, Baran, R., Kochi, H., Saito, N., Suematsu, M., Soga, T., Nishioka, T., Robert, M., BMC Bioinformatics doi:10.1186/1471-2105-7-530, 7, 530, 2006.

“Prediction of liquid chromatographic retention times of peptides generated by protease digestion of the Escherichia coli proteome using artificial neural networks”,Shinoda, K., Sugimoto, M., Yachie, N., Sugiyama, N., Masuda, T., Robert, M., Soga, T., Tomita, M., J. Proteome Res.5, 1312-1317, 2006.

“HybGFS: A hybrid method for genome-fingerprint scanning”, Shinoda, K., Yachie, N., Masuda, T., Sugiyama, N., Sugimoto, M., Soga, T., Tomita, M., BMC Bioinformatics doi:10.1186/1471-2105-7-479, 7, 479, 2006.

“Evaluation of Metabolic Alteration in Transgenic Rice Overexpressing Dihydroflavonol-4-reductase”,Takahashi, H., Hayashi, M., Sato, S., Soga, T., Nishioka, T., Tomita, M., Kawai-Yamada, M., Uchimiya, H., Ann. Bot. 98, 819-825, 2006.

“Conductivity Detection in Capillary Zone Electrophoresis - Inspection by Peak Master”, Jaros, M., Soga, T., Van de Goor, T., Gas, B., Electrophoresis 26, 1948-1953, 2005.

“Large-Scale Prediction of Cationic Metabolites Identity and Migration Time in Capillary Electrophoresis Mass Spectrometry using Artificial Neural Networks”, Sugimoto, M., Kikuchi, S., Arita, M., Soga, T., Nishioka, T., Tomita, M., Anal. Chem. 77, 78-84, 2005.

“Metabolome Analysis and Metabolic Simulation” Ishii, N., Soga, T., Nishioka, T., Tomita, M., Metabolomics 1, 29-37, 2005.

“Simultaneous Determination of Main Metabolites in Rice Leaves using Capillary Electrophoresis Mass Spectrometry and Capillary Electrophoresis Diode Array Detection” S. Sato, T. Soga, T. Nishioka, M. Tomita, Plant J. 40, 151-163, 2004.

“Qualitative and Quantitative Analysis of Amino Acids by Capillary Electrophoresis Electrospray Ionization Tandem Mass Spectrometry”T. Soga, Y. Kakazu, M. Tomita and T. Nishioka, , Electrophoresis 25, 1964-1972, 2004.

“Application of Capillary Electrophoresis Mass Spectrometry to Synthetic in vitro Glycolysis Studies ”A. Itoh, Y. Ohashi, T. Soga, H. Mori, T. Nishioka and M. Tomita,“, Electrophoresis 25, 1996-2002, 2004.

“Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry”T. Soga, Y. Ohashi, Y. Ueno, H. Naraoka, M. Tomita and T. Nishioka, J. Proteome Res. 2. 488-494, 2003.

“Pressure-Assisted Capillary Electrophoresis Electrospray Ionization Mass Spectrometry for Analysis of Multivalent Anions", T. Soga, Y. Ueno, H. Naraoka, K. Matsuda, M. Tomita and T. Nishioka, Anal. Chem., 74 6224-6229, 2002.

“Simultaneous Determination of Anionic Internediates for Bacillus subtilis Metabolic Pathways by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry", T. Soga, Y. Ueno, H. Naraoka, Y. Ohashi, M. Tomita and T. Nishioka, Anal. Chem., 74 2233-2239, 2002.

“Capillary Electrophoresis Method for the Analysis of Inorganic Anions, Organic Acids, Amino Acids, Nucleotides, Carbohydrates and Other Anionic Compounds”, T. Soga and M. Imaizumi, Electrophoresis, 22 3418-3425, 2001.

“Capillary Electrophoresis for the Determination of Forensic Anions in Adulterated Foods and Beverages”, T. Soga, I. Tajima and D.N. Heiger, Am. Lab., 32 124-128, 2000.

“Amino Acid Analysis by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry”, T. Soga and D.N. Heiger, Anal. Chem., 72 1236-1241, 2000.

“Determination of Carbohydrates in Food Samples by Capillary Electrophoresis with Indirect UV Detection”, T. Soga and M. Serwe, Food Chem., 69 339-344, 2000.

“Simultaneous Determination of Inorganic Anions, Organic Acids and Metal Cations by Capillary Electrophoresis”, T. Soga and G. A. Ross, J. Chromatogr. A, 834 ,65-71, 1999.

“Simultaneous Determination of Inorganic Anions, Organic Acids, Amino Acids and Carbohydrates by Capillary Electrophoresis”, T. Soga and G. A. Ross, J. Chromatogr. A, 837 231-239, 1999.

“Simultaneous Determination of Monosaccharides in Glycoproteins by Capillary Electrophoresis”, T. Soga and D.N. Heiger, Anal. Biochem., 261,73-78, 1998.
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慶應義塾大学鶴岡タウンキャンパス 先端生命科学研究所