Mitsuhiro Watanabe

Mitsuhiro Watanabe

Graduate School of Media and Governance
Faculty of Environment and Information StudiesProfessor
DegreesPh.D. (Universite Louis Pasteur Strasbourg, France)
Areas of ExpertiseHealth Science, Anti-aging, Metabolic Disease, Naturopathic Medicine, Preventive Medicine
Selected Publications【研究英文論文】
Ban N, Ozawa Y, Osada H, Lin JB, Toda E, Watanabe M, Yuki K, Kubota S, Apte RS, Tsubota K. Neuroprotective role of retinal SIRT3 against acute photo-stress. NPJ Aging Mech Dis. 2017 Dec 4;3:19. doi: 10.1038/s41514-017-0017-8. eCollection 2017.

Saegusa N, Sarukawa S, Ohta K, Takamatsu K, Watanabe M, Sugino T, Nakagawa M, Akiyama Y, Kusuhara M, Kishi K, Inoue K. Sutureless microvascular anastomosis assisted by an expandable shape-memory alloy stent. PLoS One. 2017 Jul 24;12(7):e0181520. doi: 10.1371/journal.pone.0181520. eCollection 2017.

Kusumoto Y, Irie J, Iwabu K, Tagawa H, Itoh A, Kato M, Kobayashi N, Tanaka K, Kikuchi R, Fujita M, Nakajima Y, Morimoto K, Sugizaki T, Yamada S, Kawai T, Watanabe M, Oike Y, Itoh H. Bile acid binding resin prevents fat accumulation through intestinal microbiota in high-fat diet-induced obesity in mice. Metabolism. 2017 Jun;71:1-6. doi: 10.1016/j.metabol.2017.02.011. Epub 2017 Feb 27. [Cited by 2]

Morimoto K, Watanabe M, Sugizaki T, Irie J, Itoh H.Intestinal Bile Acid Composition Modulates Prohormone Convertase 1/3 (PC1/3) Expression and Consequent GLP-1 Production in Male Mice.Endocrinology. 2016 Mar;157(3):1071-81.[Cited by 4]

Tagawa H, Irie J, Itoh A, Kusumoto Y, Kato M, Kobayashi N, Tanaka K, Morinaga R, Fujita M, Nakajima Y, Morimoto K, Sugizaki T, Kawano Y, Yamada S, Kawai T, Watanabe M, Itoh H. Bile acid binding resin improves hepatic insulin sensitivity by reducing cholesterol but not triglyceride levels in the liver. Diabetes Res Clin Pract. 2015 Jul;109(1):85-94. doi: 10.1016/j.diabres.2015.04.025. Epub 2015 Apr 21.[Cited by 10]

Yokoyama Y, Barnard ND, Levin SM, Watanabe M.  Vegetarian diets and glycemic control in diabetes: a systematic review and meta-analysis. Cardiovasc Diagn Ther. 2014 Oct;4(5):373-82. doi: 10.3978/j.issn.2223-3652.2014.10.04.[Cited by 83]

Matsumoto K, Imasato M, Yamazaki Y, Tanaka H, Watanabe M, Eguchi H, Nagano H, Hikita H, Tatsumi T, Takehara T, Tamura A, Tsukita S.  Claudin 2 deficiency reduces bile flow and increases susceptibility to cholesterol gallstone disease in mice. Gastroenterology. 2014 Nov;147(5):1134-45.e10. doi: 10.1053/j.gastro.2014.07.033. Epub 2014 Jul 25.[Cited by 23]

Sugizaki T, Watanabe M(Corresponding Author), Horai Y, Kaneko-Iwasaki N, Arita E, Miyazaki T, Morimoto K, Honda A, Irie J, Itoh H.  The Niemann-Pick C1 Like 1 (NPC1L1) inhibitor Ezetimibe improves metabolic disease via decreased Liver X Receptor (LXR) activity in liver of obese male mice. Endocrinology.. 2014 Apr 28:en20132143.[Cited by 13]

Sano K, Kawashima M, Ito A, Inaba T, Morimoto K, Watanabe M, Tsubota K. Aerobic exercise increases tear secretion in db/db type 2 diabetic mice. Invest Ophthalmol Vis Sci. 2014 May 29. pii: IOVS-13-13289.[Cited by 7]

Bouillon R, Carmeliet G, Lieben L, Watanabe M, Perino A, Auwerx J, Schoonjans K, Verstuyf A.  Vitamin D and energy homeostasis-of mice and men. Nature Rev Endocrinol. 2013 Nov 19. [Cited by 56]

Matsuzaki J, Suzuki H, Tsugawa H, Watanabe M, Hossain S, Arai E, Saito Y, Sekine S, Akaike T, Kanai Y, Mukaisho KI, Auwerx J, Hibi T. Bile Acids Increase Levels of microRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis. Gastroenterology. 2013 Aug 8. doi:pii: S0016-5085(13)01154-2.[Cited by 45]

Kerr TA, Matsumoto Y, Matsumoto H, Xie Y, Hirschberger LL, Stipanuk MH, Anakk S, Moore DD, Watanabe M, Kennedy S, Davidson NO. Cysteine Sulfinic Acid Decarboxylase Regulation: A Role for FXR and SHP in Murine Hepatic Taurine Metabolism. Hepatol Res. 2013 Aug 23.[Cited by 12]

Ban N, Ozawa Y, Inaba T, Miyake S, Watanabe M, Shinmura K, Tsubota K. Light-dark condition regulates sirtuin mRNA levels in the retina. Exp Gerontol. 2013 ; May 3. pii: S0531-5565(13)00108-3.[Cited by 9]

Kawashima M, Ozawa Y, Shinmura K, Inaba T, Nakamura S, Kawakita T, Watanabe M, Tsubota K. Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders. Exp Gerontol. 2013 Apr 12. pii: S0531-5565(13)00100-9.[Cited by 11]

Mizuno Y, Ninomiya Y, Nakachi Y, Iseki M, Iwasa H, Akita M, Tsukui T, Shimozawa N, Ito C, Toshimori K, Nishimukai M, Hara H, Maeba R, Okazaki T, Alodaib AN, Al Amoudi M, Jacob M, Alkuraya FS, Horai Y, Watanabe M, Motegi H, Wakana S, Noda T, Kurochkin IV, Mizuno Y, Schönbach C, Okazaki Y. Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. PLoS Genet. 2013;9(2):e1003286.[Cited by 15]

Watanabe M(Corresponding Author), Morimoto M, Houten S, Kaneko-Iwasaki N, Sugizaki T, Horai Y, Mataki C, Sato H, Murahashi K, Arita E, Schoonjans K, Suzuki T, Itoh H and Auwerx J. Bile acid binding resin improves metabolic control through the induction of energy expenditure. PLoS ONE. 2012; 7(8): e38285.[Cited by 65]

Harach T, Pols TW, Nomura M, Maida A, Watanabe M, Auwerx J, Schoonjans K.
TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.Nature. Sci Rep. 2012; 2: 430. [Cited by 97]

Kawashima M, Kawakita T, Inaba T, Okada N, Ito M, Shimmura S, Watanabe M, Shinmura K, Tsubota K. Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice. PLoS ONE. 2012; 7(3): e33148.[Cited by 36]

Ichikawa R, Takayama T, Yoneno K, Kamada N, Kitazume MT, Higuchi H, Matsuoka K, Watanabe M, Itoh H, Kanai T, Hisamatsu T, Hibi T. Bile acids induce monocyte differentiation toward IL-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology. 2012 ; 136 : 153-62.[Cited by 41]

Watanabe M (Corresponding Author), Horai Y, Houten SM, Morimoto K, Sugizaki T, Arita E, Mataki C, Sato H, Tanigawara Y, Schoonjans K, Itoh H and Auwerx J. Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure. J Biol Chem. 2011; 286: 26913-26920.[Cited by 140]

Obama T, Nagaoka S, Akagi K, Kato R, Horiuchi N, Horai Y, Aiuchi T, Arata S, Yamaguchi T, Watanabe M and Itabe H. Dietary Cholesterol Reduces Plasma Triacylglycerol in Apolipoprotein E-Knockout Mice: Suppression of Lipin-1 and Lipin-2 in the Glycerol-3-Phosphate Pathway. PLoS ONE. 2011 ; 6 : e22917.[Cited by 5]

Tamura A, Hayashi H, Imasato M, Yamazaki Y, Hagiwara A, Wada M, Noda T, Watanabe M, Suzuki Y, and Tsukita S. Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine. Gastroenterology. 2011 ; 140:913-23. [Cited by 126]

Anakk S, Watanabe M, Ochsner AS, McKenna NJ, Finegold MJ, and Moore DD. Combined deletion of FXR and SHP results in juvenile onset cholestasis and de novo induction of Cyp17A1. J Clin Invest. 2010 ; 121 : 86-95. [Cited by 41]

Nakatani H, Kasama K, Oshiro T, Watanabe M, Hirose H, Itoh H. Serum bile acid along with plasma incretins and serum high-molecular weight adiponectin levels are increased after bariatric surgery. Metabolism. 2009 ; 58: 1400-1407. [Cited by 134]

Park YJ, Qatanani M, Chua SS, LaRey JL, Johnson SA, Watanabe M, Moore DD, Lee YK. Loss of Orphan Receptore Small Heterodimer Partner Sensitizes Mice to liver injury from obstructive cholestasis. Hepatology. 2008 ; 47: 1578-1586.[Cited by 57]

Bai P, Houten SM, Huber A, Schreiber V, Watanabe M, Kiss B, de Murcia G, Auwerx J, Ménissier-de Murcia J. PARP-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the RXR/PPARgamma heterodimer. J Biol Chem. 2007; 282: 37738-37746.[Cited by 65]

Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 2006; 439: 484-489.[Cited by 1287]

Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature. 2004; 431: 200-205. [Cited by 1465]

Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest. 2004; 113: 1408-1418. [Cited by 786]

Fajas L, Annicotte JS, Miard S, Sarruf D, Watanabe M, Auwerx J. Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. J Clin Invest. 2004; 113: 1288-1295. [Cited by 89]

Mascrez B, Ghyselinck NB, Watanabe M, Annicotte JS, Chambon P, Auwerx J, Mark M. Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells. EMBO Rep. 2004; 5: 285-290.[Cited by 69]

Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A. 2003; 100: 15924-15929.[Cited by 807]

Koutnikova H, Cock TA, Watanabe M, Houten SM, Champy MF, Dierich A, Auwerx J. Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A. 2003; 100: 14457-14462.[Cited by 192]

Picard F, Wanatabe M, Schoonjans K, Lydon J, O'Malley BW, Auwerx J. Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation. Proc Natl Acad Sci U S A. 2002; 99: 15644-15648.[Cited by 101]

Schoonjans K, Watanabe M, Suzuki H, Mahfoudi A, Krey G, Wahli W, Grimaldi P, Staels B, Yamamoto T, Auwerx J. Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem. 1995; 270: 19269-19276.[Cited by 437]

Suzuki H, Watanabe M, Fujino T, Yamamoto T. Multiple promoters in rat acyl-CoA synthetase gene mediate differential expression of multiple transcripts with 5'-end heterogeneity. J Biol Chem. 1995; 270: 9676-9682.[Cited by 53]

Taoka H, Yokoyama Y, Morimoto K, Kitamura N, Tanigaki T, Takashina Y, Tsubota K, Watanabe M.Role of bile acids in the regulation of the metabolic pathways. World J Diabetes. 2016 Jul 10;7(13):260-70.[Cited by 3]

Tsubota K, Kawashima M, Inaba T, Dogru M, Matsumoto Y, Ishida R, Kaido M, Kojima T, Uchino M, Uchino Y, Ogawa Y, Nakamura S, Higuchi A, Shinmura K, Watanabe M, Kawakita T. The antiaging approach for the treatment of dry eye.
Cornea. 2012 Nov;31 Suppl 1:S3-8.[Cited by 14]

Morimoto M, Itoh H, Watanabe M(Corresponding Author). Developments in understanding bile acid metabolism. Expert Rev. Endocrinol Metab. 2013; 59-69.[Cited by 2]

Tsubota K, Kawashima M, Inaba T, Dogru M, Matsumoto Y, Ishida R, kaido M, Kojima T, Uchino M, Uchino Y, Ogawa Y, Nakamura S, Higuchi A, Shinmura K, Watanabe M, Kawakita T.The antiaging approach for the treatment of dry eye. Comea. 2012 ; 31: S3.[Cited by 14]

Houten SM, Watanabe M (equally contributed), Auwerx J. Endocrine functions of bile acids. Review. EMBO J. 2006; 25: 1419-1425.[Cited by 382]
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