Shinji Fukuda

Shinji Fukuda

Project Associate Professor
Graduate School of Media and Governance
DegreesPh.D. (Gut Microbiology), 2006, Meiji University
Other Positions Currently HeldPresident/CEO, Metabologenomics, Inc.; Research Fellow, PRESTO, JST; Group Leader, KISTEC-KAST; Visiting Professor, University of Tsukuba School of Medicine
Areas of ExpertiseIntestinal Ecosystem Regulation, Integrated Omics Science
Selected PublicationsKim, YG., Sakamoto, K., Seo, SU., Pickard, JM., Gillilland, M.G. 3rd, Pudlo, NA., Hoostal, M., Li, X., Feehley, T., Stefka, AT., Schmidt, TM., Martens, EC., Fukuda, S., Inohara, N., Nagler, CR., Nunez, G. Neonatal acquisition of clostridia species protects against colonization by bacterial pathogens. Science 356: 315-319 (2017)

Satoh, K., Yachida, S., Sugimoto, M., Oshima, M., Nakagawa, T., Akamoto, S., Tabata, S., Saitoh, K., Kato, K., Sato, S., Igarashi, K., Aizawa, Y., Kajino-Sakamoto, R., Kojima, Y., Fujishita, T., Enomoto, A., Hirayama, A., Ishikawa, T., Taketo, M.M., Kushida, Y., Haba, R., Okano, K., Tomita, M., Suzuki, Y., Fukuda, S., Aoki, M., Soga, T. Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. Proc. Natl. Acad. Sci. USA. 114: E7697-E7706 (2017)

†Mishima, E., †Fukuda, S. (†equally contributed), Mukawa, C., Yuri, A., Kanemitsu, Y., Matsumoto, Y., Akiyama, Y., Fukuda, NN., Tsukamoto, H., Asaji, K., Shima, H., Kikuchi, K., Suzuki, T., Tomioka, Y., Soga, T., Ito, S., Abe, T. Evaluation of the impact of gut microbiota on uremic solute accumulation by CE-TOFMS-based metabolomics approach. Kidney Int. 92: 634-645 (2017)

Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M., Kanai, T. Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice. Cell Rep. 20: 1513-1524 (2017)

†Mishima, E., †Fukuda, S. (†equally contributed) Shima, H., Hirayama, A., Akiyama, Y., Takeuchi, Y., Fukuda, N. N., Suzuki, T., Suzuki, C., Yuri, A., Kikuchi, K., Tomioka, Y., Ito, S., Soga, T., Abe, T. Alteration of the intestinal environment by lubiprostone is associated with amelioration of adenine-induced CKD. J. Am. Soc. Nephrol. 26: 1787-1794 (2015)

Matsumura, T., Sugawara, Y., Yutani, M., Amatsu, S., Yagita, H., Kohda, T., Fukuoka, S., Nakamura, Y., Fukuda, S., Hase, K., Ohno, H., Fujinaga, Y. Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity. Nat. Commun. 6: 6255 (2015)

†Furusawa, Y., †Obata, Y., †*Fukuda, S. (†equally contributed, *corresponding author), Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N.N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J.M., Topping, D.L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., †*Hase, K., *Ohno, H. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504: 446-450 (2013)

Okada, T., Fukuda, S., Hase, K., Nishiumi, S., Izumi, Y., Yoshida, M., Hagiwara, T., Kawashima, R., Yamazaki1, M., Oshio, T., Otsubo, T., Inagaki, O. K., Kakimoto, K., Higuchi, K., Kawamura, Y. I., Ohno, H., Dohi, T. Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice. Nat. Commun. 4: 1654 (2013)

Atarashi, K., Tanoue, T., Suda, W., Oshima, K., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., Kim, S.W., Fritz, J.V., Wilmes, P., Ueha, S., Matsushima, K., Ohno, H., Olle, B., Sakaguchi, S., Taniguchi, T., Morita, H., Hattori, M., Honda, K. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature 500: 232-236 (2013)

Kanaya, T., Hase, K., Takahashi, D., Fukuda, S., Hoshino, K., Sasaki, I., Hemmi, H., Knoop, K. A., Kumar, N., Sato, M., Katsuno, T., Yokosuka, O., Toyooka, K., Nakai, K., Sakamoto, A., Kitahara, Y., Jinnohara, T., McSorley, S. J., Kaisho, T., Williams, I. R., Ohno, H. The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. Nat. Immunol. 17: 729-736 (2012)

Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., Taylor, T. D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M., and Ohno, H. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469: 543-547 (2011)

Prakash, T., Oshima, K., Morita, H., Fukuda, S., Imaoka, A., Kumar, N., Sharma, V. K., Takahashi, M., Saitou, N., Taylor, T. D., Ohno, H., Umesaki, Y., and Hattori, M. Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation. Cell Host Microbe 10: 273-284 (2011)

Hase, K., Kawano, K., Nochi, T, Pontes, G. S., Fukuda, S., Ebisawa, M., Kadokura, K., Tobe, T., Fujimura, Y., Kawano, S., Yabashi, A., Waguri, S., Nakato, G., Kimura, S., Murakami, T., Iimura, M., Hamura, K., Fukuoka, S. I., Lowe, A. W., Itoh, K, Kiyono, H., Ohno, H. Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response. Nature 462: 226-230 (2009)
Message to StudentsFeel free to contact me, if you are interested in the research field of Health Science and Preventive Medicine.
Project Web Pagehttp://www.iab.keio.ac.jp/
Home Pagehttp://metagen.co.jp/
Contact Information14-1 Babacho Tsuruoka, Yamagata 997-0035 Japan
Keio University Tsuruoka Town Campus
sfukuda [ at ] sfc.keio.ac.jp
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